International Journal of General Medicine (Nov 2024)

D-Dimer/Platelet Ratio Predicts in-Hospital Death in Patients with Acute Type a Aortic Dissection

  • Zhao A,
  • Peng Y,
  • Luo B,
  • Chen Y,
  • Chen L,
  • Lin Y

Journal volume & issue
Vol. Volume 17
pp. 5191 – 5202

Abstract

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Ani Zhao,1,* Yanchun Peng,2,* Baolin Luo,2 Yaqin Chen,1 Liangwan Chen,3,4 Yanjuan Lin2,3 1School of Nursing, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 2Department of Nursing, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, 350001, People’s Republic of China; 3Department of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, 350001, People’s Republic of China; 4Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University) Fujian Province University, Fuzhou, Fujian Province, 350001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Liangwan Chen; Yanjuan Lin, Email [email protected]; [email protected]: Acute Type A aortic dissection (ATAAD) is a rare and life-threatening aortic disease. This study was aimed at the potential of the D-dimer to platelet count ratio (DPR) as a prognostic indicator of ATAAD.Patients and Methods: This study retrospectively analyzed ATAAD patients who were admitted to the Department of Cardiac Surgery, Fujian Medical University Union Hospital from January 2022 to April 2023. Patients were divided into survival (n = 173) and death (n = 24) groups based on whether death occurred. The primary outcome was death, and the secondary outcome was adverse hospitalization, including new postoperative arrhythmias, acute renal insufficiency, acute liver insufficiency, pleural effusion, length of ICU stay, mechanical ventilation length, and length of stay. The logistic regression model was used to analyze the relationship between DPR and in-hospital death, and the receiver operating characteristic curve (ROC) was drawn to analyze the predictive value of DPR for in-hospital death of ATAAD patients.Results: Of the 197 patients included, 24 died, and the in-hospital mortality rate was 12.2%. There was a significant difference in diastolic blood pressure (P 0.0305 ug/mL was an independent risk factor for death in ATAAD patients.Conclusion: Increased DPR is independently associated with in-hospital death in patients with ATAAD.Keywords: acute type A aortic dissection, death, D-dimer/platelet ratio, prognosis

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