The strategic mineral W-Sn deposits in China are mainly concentrated in South China, and many rare metal mineralizations, such as Li, Rb, Be, Nb, Ta, etc., are often coproduced with them. However, the genetic relationship between them is unclear. Based on the analysis of research data related to granite-related rare metals and W-Sn deposits in South China, we believe that the two types of mineralization have a close spatio-temporal relationship at multiple scales, such as metallogenic belts, ore fields, deposits, and minerals. In addition, the ore-forming material source, mineralization process, and ore-controlling structures are similar, indicating that they may have derived from a same granitic mass and the mineralization usually have close genetic relationship with the high evolved granite. Therefore, the exploration and research data of W-Sn deposits in South China can be used to explore and study rare metal deposits.