Basal Blood Morphology, Serum Biochemistry, and the Liver and Muscle Structure of Weaned Wistar Rats Prenatally Exposed to Fumonisins
Ewa Tomaszewska,
Halyna Rudyk,
Dorota Wojtysiak,
Janine Donaldson,
Siemowit Muszyński,
Marcin B. Arciszewski,
Nataliia Lisova,
Oksana Brezvyn,
Iwona Puzio,
Beata Abramowicz,
Marta Pawłowska-Olszewska,
Ihor Kotsyumbas,
Piotr Dobrowolski
Affiliations
Ewa Tomaszewska
Department of Animal Physiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Akademicka 12, 20-950 Lublin, Poland
Halyna Rudyk
State Scientific Research Control Institute of Veterinary Medicinal Products and Feed Additives, Donetska 11, 79000 Lviv, Ukraine
Dorota Wojtysiak
Department of Animal Genetics, Breeding and Ethology, Faculty of Animal Sciences, University of Agriculture in Kraków, Mickiewicza 24/28, 30-059 Cracow, Poland
Janine Donaldson
School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg 2193, South Africa
Siemowit Muszyński
Department of Biophysics, Faculty of Environmental Biology, University of Life Sciences in Lublin, Akademicka 13, 20-950 Lublin, Poland
Marcin B. Arciszewski
Department of Animal Anatomy and Histology, University of Life Sciences in Lublin, Akademicka 12, 20-950 Lublin, Poland
Nataliia Lisova
State Scientific Research Control Institute of Veterinary Medicinal Products and Feed Additives, Donetska 11, 79000 Lviv, Ukraine
Oksana Brezvyn
State Scientific Research Control Institute of Veterinary Medicinal Products and Feed Additives, Donetska 11, 79000 Lviv, Ukraine
Iwona Puzio
Department of Animal Physiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Akademicka 12, 20-950 Lublin, Poland
Beata Abramowicz
Department and Clinic of Animal Internal Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Głęboka 30, 20-612 Lublin, Poland
Marta Pawłowska-Olszewska
Department of Animal Physiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Akademicka 12, 20-950 Lublin, Poland
Ihor Kotsyumbas
State Scientific Research Control Institute of Veterinary Medicinal Products and Feed Additives, Donetska 11, 79000 Lviv, Ukraine
Piotr Dobrowolski
Department of Functional Anatomy and Cytobiology, Faculty of Biology and Biotechnology, Maria Curie-Sklodowska University, Akademicka 19, 20-033 Lublin, Poland
Cereals are often contaminated with fumonisins, which are the toxic byproducts of mold. The aim of the study was to determine the effect of maternal exposure to fumonisins on the development and the liver function of the offspring at weaning. Two doses of fumonisins (60 and 90 mg/kg b.w.) were tested. The changes in the basal blood morphology, the biochemical parameters, the absolute and relative weights of the vital organs, and the changes in the cardiac and biceps brachii muscle histology were studied. The liver damage was assessed by evaluating the liver morphology and the common clinical liver panel. Maternal fumonisin intoxication caused a decrease in the body weight at birth and an increase in the heart, liver, kidney, lungs, ovaries, and testes weights. The cytokines and hormones, as well as the red blood cell counts and hemoglobin levels, were elevated in a dose-dependent manner following the exposure to fumonisins. Maternal exposure caused degenerative morphological and structural changes in the liver, as well as inflammation in the striated muscles, such as the heart and biceps brachii, and disproportionate development of the rat offspring in a dose-dependent manner. Moreover, FB exposure resulted in the disproportional development of the rat offspring in a dose-dependent manner, which was probably caused by the bodily hormonal dysregulation. Prenatal fumonisin exposure can be a pathological precursor for serious diseases, such as obesity and diabetes, later in life.
