Nature Communications (Jan 2016)
Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2–JNK signalling in breast cancer
- Tania M. Puvirajesinghe,
- François Bertucci,
- Ashish Jain,
- Pierluigi Scerbo,
- Edwige Belotti,
- Stéphane Audebert,
- Michael Sebbagh,
- Marc Lopez,
- Andreas Brech,
- Pascal Finetti,
- Emmanuelle Charafe-Jauffret,
- Max Chaffanet,
- Rémy Castellano,
- Audrey Restouin,
- Sylvie Marchetto,
- Yves Collette,
- Anthony Gonçalvès,
- Ian Macara,
- Daniel Birnbaum,
- Laurent Kodjabachian,
- Terje Johansen,
- Jean-Paul Borg
Affiliations
- Tania M. Puvirajesinghe
- CRCM, Cell Polarity, Cell signalling and Cancer ‘Equipe labellisée Ligue Contre le Cancer’
- François Bertucci
- Institut Paoli-Calmettes
- Ashish Jain
- Department of Medical Biology, Molecular Cancer Research Group, University of Tromsø—The Arctic University of Norway
- Pierluigi Scerbo
- Institut de Biologie du Développement de Marseille, Aix-Marseille Université, CNRS UMR 7288
- Edwige Belotti
- CRCM, Cell Polarity, Cell signalling and Cancer ‘Equipe labellisée Ligue Contre le Cancer’
- Stéphane Audebert
- Institut Paoli-Calmettes
- Michael Sebbagh
- CRCM, Cell Polarity, Cell signalling and Cancer ‘Equipe labellisée Ligue Contre le Cancer’
- Marc Lopez
- Institut Paoli-Calmettes
- Andreas Brech
- Department of Molecular Cell Biology, Centre for Cancer Biomedicine, University of Oslo and Institute for Cancer Research, The Norwegian Radium Hospital
- Pascal Finetti
- Institut Paoli-Calmettes
- Emmanuelle Charafe-Jauffret
- Institut Paoli-Calmettes
- Max Chaffanet
- Institut Paoli-Calmettes
- Rémy Castellano
- Institut Paoli-Calmettes
- Audrey Restouin
- Institut Paoli-Calmettes
- Sylvie Marchetto
- CRCM, Cell Polarity, Cell signalling and Cancer ‘Equipe labellisée Ligue Contre le Cancer’
- Yves Collette
- Institut Paoli-Calmettes
- Anthony Gonçalvès
- CRCM, Cell Polarity, Cell signalling and Cancer ‘Equipe labellisée Ligue Contre le Cancer’
- Ian Macara
- Department of Microbiology, University of Virginia School of Medicine
- Daniel Birnbaum
- Institut Paoli-Calmettes
- Laurent Kodjabachian
- Institut de Biologie du Développement de Marseille, Aix-Marseille Université, CNRS UMR 7288
- Terje Johansen
- Department of Medical Biology, Molecular Cancer Research Group, University of Tromsø—The Arctic University of Norway
- Jean-Paul Borg
- CRCM, Cell Polarity, Cell signalling and Cancer ‘Equipe labellisée Ligue Contre le Cancer’
- DOI
- https://doi.org/10.1038/ncomms10318
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 15
Abstract
Defects in non-canonical Wnt/planar cell polarity signalling have recently been linked to breast cancer aggressiveness. Puvirajesinghe et al. identify VANGL2, p62/SQSTM1 and JNK as important players in this pathway which may be amenable to therapeutic intervention in breast cancer.
