Antiradical and immunomodulatory effects of gynecological capsules developed for complex treatment of diseases of the female reproductive system

Abstract

Aim of the study was to evaluate the antiradical and immunomodulatory effects of gynecological capsules (ovules) developed for the complex treatment of diseases of the female reproductive system.Material and methods. Antiradical activity of gynecological capsules (ovuli) was evaluated in cell-free model systems by the ability to suppress the hyperproduction of free radical agents caused by the introduction of iron sulfate. Immunomodulatory activity was determined in the whole blood by their effect on the ability of phagocytic cells to generate reactive oxygen species.Results. In cell-free model systems, the studied drug composition suppressed the activation of free radical oxidative processes induced by the iron sulfate, while at the same time enhancing the production of reactive oxygen species by leukocytes.Conclusions. The results obtained may indicate that the developed gynecological capsules have antiradical and immunomodulatory activity, which allows us to consider them as a promising tool for the treatment of diseases of the female reproductive system.

Keywords

• gynecology
• inflammation
• chemiluminescence
• oxidative stress
• free radicals
• immunomodulators