Tyramide-conjugated DNA barcodes enable signal amplification for multiparametric CODEX imaging

Paul D. Simonson; Itzel Valencia; Sanjay S. Patel

doi:10.1038/s42003-022-03558-8

Communications Biology (Jun 2022)

Tyramide-conjugated DNA barcodes enable signal amplification for multiparametric CODEX imaging

Paul D. Simonson,
Itzel Valencia,
Sanjay S. Patel

Affiliations

Paul D. Simonson: Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
Itzel Valencia: Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
Sanjay S. Patel: Department of Pathology and Laboratory Medicine, Weill Cornell Medicine

DOI: https://doi.org/10.1038/s42003-022-03558-8
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 11

Abstract

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Tyramide-conjugated DNA barcodes can be used to perform CODEX imaging without modifying primary antibodies and could complement existing CODEX workflows for multiplexed imaging.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal