Alzheimer’s Research & Therapy (Oct 2023)
Is the clinical phenotype impact the prognosis in dementia with Lewy bodies?
Abstract
Abstract Introduction The first predominant clinical symptoms of dementia with Lewy bodies (DLB) are highly variable; however, the prognosis based on initial predominant symptoms remains poorly understood. Methods Multicenter retrospective study in 4 French expert neurological centers. Patients were categorized in 3 groups according to their first more predominant symptoms: cognitive, psychiatric, or motor. Results Analysis of 310 DLB patients. The mean age was 73.5 years old (SD 7.5) including 32.3% of women. The mean follow-up was 7.25 years (SD 3.6). We observed that the full clinical picture was more frequent in the motor group than in the cognitive group (p = 0.01); male gender and age at onset were associated with a significant excess risk of instantaneous mortality (p = 0.01). Conclusion Initial symptoms may affect the clinical course of patients, but no significant difference in mortality was observed.
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