Cryo-EM structure of the human ferritin–transferrin receptor 1 complex

Linda Celeste Montemiglio; Claudia Testi; Pierpaolo Ceci; Elisabetta Falvo; Martina Pitea; Carmelinda Savino; Alessandro Arcovito; Giovanna Peruzzi; Paola Baiocco; Filippo Mancia; Alberto Boffi; Amédée des Georges; Beatrice Vallone

doi:10.1038/s41467-019-09098-w

Nature Communications (Mar 2019)

Cryo-EM structure of the human ferritin–transferrin receptor 1 complex

Linda Celeste Montemiglio,
Claudia Testi,
Pierpaolo Ceci,
Elisabetta Falvo,
Martina Pitea,
Carmelinda Savino,
Alessandro Arcovito,
Giovanna Peruzzi,
Paola Baiocco,
Filippo Mancia,
Alberto Boffi,
Amédée des Georges,
Beatrice Vallone

Affiliations

Linda Celeste Montemiglio: Department of Biochemical Sciences “Alessandro Rossi Fanelli”, Sapienza University of Rome
Claudia Testi: Department of Biochemical Sciences “Alessandro Rossi Fanelli”, Sapienza University of Rome
Pierpaolo Ceci: Institute of Molecular Biology and Pathology, National Research Council
Elisabetta Falvo: Institute of Molecular Biology and Pathology, National Research Council
Martina Pitea: Department of Biochemical Sciences “Alessandro Rossi Fanelli”, Sapienza University of Rome
Carmelinda Savino: Institute of Molecular Biology and Pathology, National Research Council
Alessandro Arcovito: Istituto di Biochimica e Biochimica Clinica, Università Cattolica del Sacro Cuore
Giovanna Peruzzi: Center for Life Nano Science @ Sapienza, Istituto Italiano di Tecnologia
Paola Baiocco: Center for Life Nano Science @ Sapienza, Istituto Italiano di Tecnologia
Filippo Mancia: Department of Physiology and Cellular Biophysics, Russ Berrie Pavilion, Columbia University Medical Center
Alberto Boffi: Department of Biochemical Sciences “Alessandro Rossi Fanelli”, Sapienza University of Rome
Amédée des Georges: Advanced Science Research Center at The Graduate Center of the City University of New York
Beatrice Vallone: Department of Biochemical Sciences “Alessandro Rossi Fanelli”, Sapienza University of Rome

DOI: https://doi.org/10.1038/s41467-019-09098-w
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 8

Abstract

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The human transferrin receptor 1 (CD71) is a transmembrane protein responsible for iron uptake. Here the authors present the 3.9 Å resolution cryo-EM structure of the CD71 ectodomain-human ferritin (H-Ft) complex and find that H-Ft binds a CD71 region different from the transferrin one that overlaps with the surface recognized by select pathogens.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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