Pharmacogenomics perspective for forensic toxicology: A mini review

Abstract

Pharmacogenetic and Pharmacogenomics are the study of the association between an individual's genotype and their response to xenobiotics Pharmacokinetic and pharmacodynamics variations can appear at the level of drug-metabolizing enzymes, drug transporters, drug targets or other biomarker genes. Pharmacogenomics can, therefore, be relevant in forensic toxicology. This review presents relevant aspects together with some examples from daily routines. Use of pharmacogenomics in forensic toxicology may add to the understanding of drug toxicity due to genetically predisposed impaired drug metabolism and may provide findings which may be back-extrapolated for the benefits of optimization of antemortem drug therapy. [Med-Science 2022; 11(4.000): 1738-44]

Keywords

• forensic toxicology
• pharmacogenomics
• pharmacogenetics
• toxicology