Nature Communications (Nov 2016)
Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism
- Renee L. Greer,
- Xiaoxi Dong,
- Ana Carolina F. Moraes,
- Ryszard A. Zielke,
- Gabriel R. Fernandes,
- Ekaterina Peremyslova,
- Stephany Vasquez-Perez,
- Alexi A. Schoenborn,
- Everton P. Gomes,
- Alexandre C. Pereira,
- Sandra R. G. Ferreira,
- Michael Yao,
- Ivan J. Fuss,
- Warren Strober,
- Aleksandra E. Sikora,
- Gregory A. Taylor,
- Ajay S. Gulati,
- Andrey Morgun,
- Natalia Shulzhenko
Affiliations
- Renee L. Greer
- College of Veterinary Medicine, Oregon State University
- Xiaoxi Dong
- College of Pharmacy, Oregon State University
- Ana Carolina F. Moraes
- Department of Epidemiology, School of Public Health, University of São Paulo
- Ryszard A. Zielke
- College of Pharmacy, Oregon State University
- Gabriel R. Fernandes
- Oswaldo Cruz Foundation, René Rachou Research Center
- Ekaterina Peremyslova
- College of Pharmacy, Oregon State University
- Stephany Vasquez-Perez
- College of Veterinary Medicine, Oregon State University
- Alexi A. Schoenborn
- Division of Pediatric Gastroenterology, University of North Carolina at Chapel Hill
- Everton P. Gomes
- Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School
- Alexandre C. Pereira
- Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School
- Sandra R. G. Ferreira
- Department of Epidemiology, School of Public Health, University of São Paulo
- Michael Yao
- Mucosal Immunity Section, Laboratory of Immune Defenses, National Institute of Allergy and Infectious Diseases
- Ivan J. Fuss
- Mucosal Immunity Section, Laboratory of Immune Defenses, National Institute of Allergy and Infectious Diseases
- Warren Strober
- Mucosal Immunity Section, Laboratory of Immune Defenses, National Institute of Allergy and Infectious Diseases
- Aleksandra E. Sikora
- College of Pharmacy, Oregon State University
- Gregory A. Taylor
- Departments of Medicine, Division of Geriatrics and Center for the Study of Aging and Human Development, Geriatric Research, Education and Clinical Center, VA Medical Center, Molecular Genetics and Microbiology and Immunology
- Ajay S. Gulati
- Division of Pediatric Gastroenterology, University of North Carolina at Chapel Hill
- Andrey Morgun
- College of Pharmacy, Oregon State University
- Natalia Shulzhenko
- College of Veterinary Medicine, Oregon State University
- DOI
- https://doi.org/10.1038/ncomms13329
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 13
Abstract
Mice deficient in the pro-inflammatory cytokine IFNγ have improved glucose tolerance. Here, the authors show that this effect depends on the gut microbeAkkermansia muciniphila, whose abundance increases in the absence IFNγ, and which is known to have beneficial effects on host metabolism.
