Nature Communications (Jan 2017)
Repo-Man/PP1 regulates heterochromatin formation in interphase
- Inês J. de Castro,
- James Budzak,
- Maria L. Di Giacinto,
- Lorena Ligammari,
- Ezgi Gokhan,
- Christos Spanos,
- Daniela Moralli,
- Christine Richardson,
- Jose I. de las Heras,
- Silvia Salatino,
- Eric C. Schirmer,
- Katharine S. Ullman,
- Wendy A. Bickmore,
- Catherine Green,
- Juri Rappsilber,
- Sarah Lamble,
- Martin W. Goldberg,
- Veronica Vinciotti,
- Paola Vagnarelli
Affiliations
- Inês J. de Castro
- College of Health and Life Science, Research Institute for Environment Health and Society, Brunel University London
- James Budzak
- College of Health and Life Science, Research Institute for Environment Health and Society, Brunel University London
- Maria L. Di Giacinto
- College of Health and Life Science, Research Institute for Environment Health and Society, Brunel University London
- Lorena Ligammari
- College of Health and Life Science, Research Institute for Environment Health and Society, Brunel University London
- Ezgi Gokhan
- College of Health and Life Science, Research Institute for Environment Health and Society, Brunel University London
- Christos Spanos
- Wellcome Trust Centre for Cell Biology
- Daniela Moralli
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Christine Richardson
- School of Biological and Medical Science, Durham University
- Jose I. de las Heras
- Wellcome Trust Centre for Cell Biology
- Silvia Salatino
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Eric C. Schirmer
- Wellcome Trust Centre for Cell Biology
- Katharine S. Ullman
- Huntsman Cancer Institute, University of Utah
- Wendy A. Bickmore
- MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Catherine Green
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Juri Rappsilber
- Wellcome Trust Centre for Cell Biology
- Sarah Lamble
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Martin W. Goldberg
- School of Biological and Medical Science, Durham University
- Veronica Vinciotti
- College of Engineering, Design and Technology, Research Institute for Environment Health and Society, Brunel University London
- Paola Vagnarelli
- College of Health and Life Science, Research Institute for Environment Health and Society, Brunel University London
- DOI
- https://doi.org/10.1038/ncomms14048
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 16
Abstract
Repo-Man is a chromosome-binding subunit of protein phosphatase 1 to regulate mitosis. Here, de Castro and colleagues show that Repo-Man also regulates heterochromatin during interphase, and regulates gene repression and chromatin organization.
