Human Basigin (CD147) Does Not Directly Interact with SARS-CoV-2 Spike Glycoprotein

Robert J. Ragotte; David Pulido; Francesca R. Donnellan; Michelle L. Hill; Giacomo Gorini; Hannah Davies; Juliane Brun; Kirsty McHugh; Lloyd D. W. King; Katherine Skinner; Kazutoyo Miura; Carole A. Long; Nicole Zitzmann; Simon J. Draper

doi:10.1128/mSphere.00647-21

mSphere (Aug 2021)

Human Basigin (CD147) Does Not Directly Interact with SARS-CoV-2 Spike Glycoprotein

Robert J. Ragotte,
David Pulido,
Francesca R. Donnellan,
Michelle L. Hill,
Giacomo Gorini,
Hannah Davies,
Juliane Brun,
Kirsty McHugh,
Lloyd D. W. King,
Katherine Skinner,
Kazutoyo Miura,
Carole A. Long,
Nicole Zitzmann,
Simon J. Draper

Affiliations

Robert J. Ragotte: ORCiD; Jenner Institute, University of Oxford, Oxford, United Kingdom
David Pulido: Jenner Institute, University of Oxford, Oxford, United Kingdom
Francesca R. Donnellan: Jenner Institute, University of Oxford, Oxford, United Kingdom
Michelle L. Hill: Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford, United Kingdom
Giacomo Gorini: Jenner Institute, University of Oxford, Oxford, United Kingdom
Hannah Davies: Jenner Institute, University of Oxford, Oxford, United Kingdom
Juliane Brun: Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford, United Kingdom
Kirsty McHugh: Jenner Institute, University of Oxford, Oxford, United Kingdom
Lloyd D. W. King: Jenner Institute, University of Oxford, Oxford, United Kingdom
Katherine Skinner: Jenner Institute, University of Oxford, Oxford, United Kingdom
Kazutoyo Miura: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Carole A. Long: Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Nicole Zitzmann: Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford, United Kingdom
Simon J. Draper: Jenner Institute, University of Oxford, Oxford, United Kingdom

DOI: https://doi.org/10.1128/mSphere.00647-21
Journal volume & issue: Vol. 6, no. 4

Abstract

Read online

Reducing the mortality and morbidity associated with COVID-19 remains a global health priority. Vaccines have proven highly effective at preventing infection and hospitalization, but efforts must continue to improve treatment options for those who still become seriously ill.

Published in mSphere

ISSN: 2379-5042 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/msphere

About the journal