Immune response – genesis, duration, and strength in patients with moderate and severe coronavirus infection of different age groups

Abstract

Acquired (adaptive) immunity is a major factor determining effective immune response against a few infectious diseases. The immune response during recovery from COVID-19 is complex, involving both cellular and humoral adaptive immunity. The purpose of the study is to determine the intensity and effectiveness of the immune response at the end of the second year after discharge from the hospital in patients who have suffered from moderate and severe forms of coronavirus infection. A study among 2683 patients who suffered from moderately severe and severe coronavirus SARS-CoV2 infection with recorded complications which have not received a vaccine against SARS-nCoV-2 was performed. In the studied group of patients there were no deaths. In the whole cohort, the share of underlying prehospital comorbidity was also analyzed. The immune response induced because of moderate and severe infection with COVID-19 could serve as source of protection from recurrent severe infection for patents of different ages with various comorbidities.