TRAb negative entities of hyperthyroid syndrome: Our experience of the past 5 years

Abstract

Over the past five years, since we moved to private practice, we continued with testing of TSH receptor antibodies. So far we have carried out 775 tests and examined 260 patients. We used TRAb human, BRAHMs. We carried out our research on 192 patients with untreated immune hyperthyroidism and 37 with the disease in remission. As the subject of this study was TRAb negative hyperthyroidism, the examination of this group of patients was comprehensive. The largest was a group of patients with Plummer disease (13 in total - 4 with toxic adenoma, 7 with multinodular toxic goiter and 2 with disseminated thyroid autonomy).Nine experienced thyroid destruction (eight with painful thyroiditis, one with post-partal thyroiditis and one with thyroid infarction). Five patients had amiodaron induced hyperthyroidism. Diagnosis was based on the following criteria: clinical features and symptoms, 'free' thyroxin concentration, concentration of ultrasensitive TSH, ultrasonography of thyroid gland and scinigraphy with Tc 99m pertehnetat. The analysis of each method was used for diagnosis and differential diagnosis of each type of occurrences of TRAb negative hyperthyroidism.