Reinvestigation of the Automated Synthesis of Stoichiometrically Conjugated Antibodies to Access High Molecular Weight Payloads and Multiplexed Conjugation via an In-Solution Trans-Tagging Process

• Victor Lehot,
• Ondřej Lidický,
• Julien Most,
• Stéphane Erb,
• Igor Dovgan,
• Artem Osypenko,
• Oleksandr Koniev,
• Sergii Kolodych,
• Lenka Kotrchová,
• Guilhem Chaubet,
• Sarah Cianférani,
• Tomáš Etrych,
• Alain Wagner

Affiliations

Victor Lehot

Bio-Functional Chemistry (UMR 7199), Institut du Médicament de Strasbourg, University of Strasbourg, Illkirch-Graffenstaden, France

Ondřej Lidický

Institute of Macromolecular Chemistry, Czech Academy of Sciences, Prague 6, Czechia

Julien Most

Bio-Functional Chemistry (UMR 7199), Institut du Médicament de Strasbourg, University of Strasbourg, Illkirch-Graffenstaden, France

Stéphane Erb

Laboratoire de Spectrométrie de Masse BioOrganique (LSMBO), Institut du Médicament de Strasbourg, Université de Strasbourg, CNRS, IPHC UMR 7178, Strasbourg, France

Igor Dovgan

Syndivia SAS, Strasbourg, France

Artem Osypenko

Syndivia SAS, Strasbourg, France

Oleksandr Koniev

Syndivia SAS, Strasbourg, France

Sergii Kolodych

Syndivia SAS, Strasbourg, France

Lenka Kotrchová

Institute of Macromolecular Chemistry, Czech Academy of Sciences, Prague 6, Czechia

Guilhem Chaubet

Bio-Functional Chemistry (UMR 7199), Institut du Médicament de Strasbourg, University of Strasbourg, Illkirch-Graffenstaden, France

Sarah Cianférani

Laboratoire de Spectrométrie de Masse BioOrganique (LSMBO), Institut du Médicament de Strasbourg, Université de Strasbourg, CNRS, IPHC UMR 7178, Strasbourg, France

Tomáš Etrych

Institute of Macromolecular Chemistry, Czech Academy of Sciences, Prague 6, Czechia

Alain Wagner

Bio-Functional Chemistry (UMR 7199), Institut du Médicament de Strasbourg, University of Strasbourg, Illkirch-Graffenstaden, France