Changes of gelatinases activity in rats with anthracycline cardiopathy at application of nonsteroid antiinflammatory drugs and quercetin

Abstract

The activity of gelatinases A and B in blood plasma of rats with doxorubicin-induced cardiopathy at the application of cyclooxygenases inhibitors – ketorolak, lornoxycam and celecoxib was investigated. Significant increase of activity of both gelatinases in rats with cardiopathy was identified. Under ketorolak effect gelatinase B activity increases, and gelatinase A is inhibi­ted. The opposite reaction was observed when celecoxib was applied: gelatinase B acti­vity decreases, and gelatinase A increases. Combination of bioflavonoid quercetin and COX inhibitors decreased the activity of both latent forms of gelatinases in blood plasma of rats with cardiopathy. It is concluded that the stabilization of gelatinases activity is an indicator of myocardial metabolism and additional indicator of fibrosis development.

Keywords

• gelatinases a and b
• cardiopathy
• cox inhibitors
• quercetin