Nanotechnology and nucleic acid nanoparticles for treatment of metabolic disorders
Dinh-Toi Chu,
Hue Vu Thi,
Tiep Tien Nguyen,
Thuy-Duong Vu,
Yen Vy Nguyen Thi,
Indra Mani,
Nisarg Gohil,
Gargi Bhattacharjee,
Suresh Ramakrishna,
Vijai Singh
Affiliations
Dinh-Toi Chu
Center for Biomedicine and Community Health, International School, Vietnam National University, Hanoi, Viet Nam; Faculty of Applied Sciences, International School, Vietnam National University, Hanoi, Viet Nam; Corresponding author.
Hue Vu Thi
Center for Biomedicine and Community Health, International School, Vietnam National University, Hanoi, Viet Nam; Faculty of Applied Sciences, International School, Vietnam National University, Hanoi, Viet Nam
Tiep Tien Nguyen
Center for Biomedicine and Community Health, International School, Vietnam National University, Hanoi, Viet Nam; Epibiotech Co. Ltd., Incheon 21983, Republic of Korea
Thuy-Duong Vu
Center for Biomedicine and Community Health, International School, Vietnam National University, Hanoi, Viet Nam
Yen Vy Nguyen Thi
Center for Biomedicine and Community Health, International School, Vietnam National University, Hanoi, Viet Nam; Faculty of Applied Sciences, International School, Vietnam National University, Hanoi, Viet Nam
Indra Mani
Department of Microbiology, Gargi College, University of Delhi, New Delhi, India
Nisarg Gohil
Department of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana, 382715, Gujarat, India
Gargi Bhattacharjee
Department of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana, 382715, Gujarat, India
Suresh Ramakrishna
College of Medicine, Hanyang University, Seoul, South Korea; Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, South Korea
Vijai Singh
Department of Biosciences, School of Science, Indrashil University, Rajpur, Mehsana, 382715, Gujarat, India; Corresponding author.
Metabolic disorders result from inborn and acquired dysfunction of organs and tissues that are responsible for producing energy in the body. These diseases are now among the most prevalent maladies in the world. Treatment often requires addressing individual conditions, including obesity, diabetes, and liver diseases with a combination of multiple drugs. Accumulating evidence shows that the defects or overexpression of some specific genes in the diseased organ cause such diseases. Therefore, advanced options are required to control them at the molecular level. In this review, we highlight the current approaches of nanotechnologies, especially for delivering exogenous nucleic acid nanoparticles to treat metabolic disorders. We also summarize the mechanisms of how various nucleic acid nanoparticles have been utilized, the trends, and the potential applications of these materials in metabolic disorders. Greater knowledge of nanotechnologies and nucleic acid particles may pave the way to cure these prevalent diseases effectively.
