Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul (Apr 2009)
Association of Follicular Response with Outcome of Intrauterine Insemination in Infertile Women
Abstract
BACKGROUND AND OBJECTIVE: Intrauterine insemination (IUI) after ovulation induction is one of the infertility treatment methods that used before more invasive assisted reproductive techniques (ART) due to simplicity and low expenses. This procedure is performed in different kinds of subfertility such as male factors, cervical factors and unexplained infertility. The aim of this study was to determine the association of follicular response with IUI outcome.METHODS: This case-control study was done on 267 infertile couples under 35 years old in Fatemeh Zahra infertility center affiliated to Babol University of medical sciences, Babol, Iran that the result of IUI was positive in 89 cases and it was negative in 178 cases. Women with cervical factor and ovulation dysfunction who underwent clomiphene citrate, or clomiphene citrate and human menopausal gonadotropin were included in this study. Data include: age, duration of infertility, follicle number, number of IUI cycles and outcome were analyzed. FINDINGS: Pregnancy occurred in 89(33.3%) of 267 cases. The number of follicle in pregnant women (2.8±1.4) was significantly higher than non-pregnant women (1.9±0.9) (p=0.000). The mean age of pregnant women (24.3±3.8 years) was significantly lower than non-pregnant women (26.4±4.8 years) (p=0.000). The duration of infertility in pregnant women (2.67±2.3 years) was significantly lower than non-pregnant women (4.5±3.1 years) (p=0.000). There was not significant correlation between number of follicle with women age (p=0.599, r=0.032) and duration of infertility (p=0.475, r=-0.044)CONCLUSION: According to the results of this study, success of IUI in ovarian stimulation cycles depended on the number of follicle. So it is recommended to consider the number of follicle for success of IUI in ovarian stimulation cycles.
