Bulletin of the Chemical Society of Ethiopia (Jan 2018)

A 3D polyhedral metal–organic framework as drug carrier for controllable release

  • E. H. Zhou,
  • R. Wang,
  • J. Wu,
  • S. W. Qiu,
  • J. Q. Liu,
  • H. R. Zhong,
  • H. D. Zeng,
  • J. W. Xu,
  • J. C. Jin

DOI
https://doi.org/10.4314/bcse.v31i3.9
Journal volume & issue
Vol. 31, no. 3
pp. 457 – 463

Abstract

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A new fabrication of {[H3O][Cu6(tpta)3(DMA)4(COO)]∙12H2O∙7DMA} (1) was used as a drug vehicle of 5-fluorouracil (5-FU) for drug delivery. The incorporation of the drug 5-FU into the 1 was around 47.3 wt% per gram of dehydrated 1. Cargo release behavior and material degradation profile were also investigated under different mdeium. 5-FU is released in a highly controlled and progressive manner with 92% of the drug release after 96 h at acidic condition and with 88% after 96 h at PBS. In vitro cytotoxicity assays indicated that the 1 possesses no obvious cytotoxicity. The results provide a new avenue for MOFs to be used as potential drug delivery.

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