Butenolide Derivatives with α-Glucosidase Inhibitions from the Deep-Sea-Derived Fungus <i>Aspergillus terreus</i> YPGA10

Abstract

Three new butenolide derivatives, namely aspernolides N−P (1−3), together with six known analogues (4−9), were isolated from the ethyl acetate (EtOAc) extract of the deep sea-derived fungus Aspergillus terreus YPGA10. The structures of compounds 1−3 were determined on the basis of comprehensive analyses of the nuclear magnetic resonance (NMR) and mass spectroscopy (MS) data, and the absolute configurations of 1 and 2 were determined by comparisons of experimental electronic circular dichroism (ECD) with calculated ECD spectra. Compound 1 represents the rare example of Aspergillus-derived butenolide derivatives featured by a monosubstituted benzene ring. Compounds 6−9 exhibited remarkable inhibitory effects against α-glucosidase with IC50 values of 3.87, 1.37, 6.98, and 8.06 μM, respectively, being much more active than the positive control acarbose (190.2 μM).

Keywords

• <i>Aspergillus terreus</i> YPGA10
• deep-sea-derived fungus
• butenolide derivatives
• <i>α</i>-glucosidase