KRAS-related noncoding RNAs in pancreatic ductal adenocarcinoma

Shuang-Ni Yu; Yi-Hui Ma; Wu-Gan Zhao; Xiang-Lan Jin; Hai-Yan Yang; Ping-Ping Liu; Jie Chen

Chronic Diseases and Translational Medicine (Dec 2016)

KRAS-related noncoding RNAs in pancreatic ductal adenocarcinoma

Shuang-Ni Yu,
Yi-Hui Ma,
Wu-Gan Zhao,
Xiang-Lan Jin,
Hai-Yan Yang,
Ping-Ping Liu,
Jie Chen

Affiliations

Shuang-Ni Yu: Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tsinghua University, Beijing 100730, China
Yi-Hui Ma: Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tsinghua University, Beijing 100730, China; Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China
Wu-Gan Zhao: Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tsinghua University, Beijing 100730, China; Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China
Xiang-Lan Jin: Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tsinghua University, Beijing 100730, China; Department of Pathology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, China
Hai-Yan Yang: Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tsinghua University, Beijing 100730, China; Department of Pathology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China
Ping-Ping Liu: Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tsinghua University, Beijing 100730, China; Department of Pathology, China-Japan Friendship Hospital, Beijing 100029, China
Jie Chen: Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tsinghua University, Beijing 100730, China; Corresponding author.

Journal volume & issue: Vol. 2, no. 4
pp. 215 – 222

Abstract

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Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a poor overall prognosis. However, curative resection during the early stages of the disease can greatly improve survival rates, highlighting the importance of early screening and detection. Studies of noncoding RNAs, primarily microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), provide important insights into strategies for the early detection of KRAS-driven PDAC. Here, we summarize our studies and review current reports on research investigating KRAS-related miRNAs and lncRNAs, emphasizing their aberrant expression, mechanisms, carcinogenic effects, and prognostic and predictive capacities in PDAC. Keywords: Pancreatic ductal adenocarcinoma, KRAS, Noncoding RNAs, microRNAs, Long noncoding RNAs

Published in Chronic Diseases and Translational Medicine

ISSN: 2095-882X (Print); 2589-0514 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Medicine (General)
Website: https://onlinelibrary.wiley.com/journal/25890514

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