Human evolved regulatory elements modulate genes involved in cortical expansion and neurodevelopmental disease susceptibility

Hyejung Won; Jerry Huang; Carli K. Opland; Chris L. Hartl; Daniel H. Geschwind

doi:10.1038/s41467-019-10248-3

Nature Communications (Jun 2019)

Human evolved regulatory elements modulate genes involved in cortical expansion and neurodevelopmental disease susceptibility

Hyejung Won,
Jerry Huang,
Carli K. Opland,
Chris L. Hartl,
Daniel H. Geschwind

Affiliations

Hyejung Won: Neurogenetics Program, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles
Jerry Huang: Neurogenetics Program, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles
Carli K. Opland: Neurogenetics Program, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles
Chris L. Hartl: Neurogenetics Program, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles
Daniel H. Geschwind: Neurogenetics Program, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles

DOI: https://doi.org/10.1038/s41467-019-10248-3
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

Read online

Different classes of human evolved regulatory elements are located in non-coding regions of the genome. The authors connect the expansion of the cortical surface and connectivity with human evolved elements and show that their target genes are involved in neurodevelopmental disease susceptibility.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal