A Comparative Evaluation of Multiparametric Magnetic Resonance Imaging and Micro-Ultrasound for the Detection of Clinically Significant Prostate Cancer in Patients with Prior Negative Biopsies
Edoardo Beatrici,
Nicola Frego,
Giuseppe Chiarelli,
Federica Sordelli,
Stefano Mancon,
Cesare Saitta,
Fabio De Carne,
Giuseppe Garofano,
Paola Arena,
Pier Paolo Avolio,
Andrea Gobbo,
Alessandro Uleri,
Roberto Contieri,
Marco Paciotti,
Massimo Lazzeri,
Rodolfo Hurle,
Paolo Casale,
Nicolò Maria Buffi,
Giovanni Lughezzani
Affiliations
Edoardo Beatrici
Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, Italy
Nicola Frego
Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, Italy
Giuseppe Chiarelli
Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, Italy
Federica Sordelli
Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, Italy
Stefano Mancon
Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, Italy
Cesare Saitta
Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, Italy
Fabio De Carne
Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, Italy
Giuseppe Garofano
Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, Italy
Paola Arena
Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, Italy
Pier Paolo Avolio
Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, Italy
Andrea Gobbo
Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, Italy
Alessandro Uleri
Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, Italy
Roberto Contieri
Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, Italy
Marco Paciotti
Department of Urology, IRCCS Humanitas Research Hospital, 20089 Rozzano, MI, Italy
Massimo Lazzeri
Department of Urology, IRCCS Humanitas Research Hospital, 20089 Rozzano, MI, Italy
Rodolfo Hurle
Department of Urology, IRCCS Humanitas Research Hospital, 20089 Rozzano, MI, Italy
Paolo Casale
Department of Urology, IRCCS Humanitas Research Hospital, 20089 Rozzano, MI, Italy
Nicolò Maria Buffi
Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, Italy
Giovanni Lughezzani
Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, Italy
Background: The diagnostic process for prostate cancer after a negative biopsy is challenging. This study compares the diagnostic accuracy of micro-ultrasound (mUS) with multiparametric magnetic resonance imaging (mpMRI) for such cases. Methods: A retrospective cohort study was performed, targeting men with previous negative biopsies and using mUS and mpMRI to detect prostate cancer and clinically significant prostate cancer (csPCa). Results: In our cohort of 1397 men, 304 had a history of negative biopsies. mUS was more sensitive than mpMRI, with better predictive value for negative results. Importantly, mUS was significantly associated with csPCa detection (adjusted odds ratio [aOR]: 6.58; 95% confidence interval [CI]: 1.15–37.8; p = 0.035). Conclusions: mUS may be preferable for diagnosing prostate cancer in previously biopsy-negative patients. However, the retrospective design of this study at a single institution suggests that further research across multiple centers is warranted.
