The transformation of a nation can basically be achieved through the advancement of science and technology. Ethiopia has long recognized the role of science and technology in bringing about sustainable development. The country has envisioned transforming itself into a middle-income country in 2025. To this end the country has exerted relentless efforts to materialize science and technology in the country. Thus, it has made science and technology the pillar of its top priorities for transformation of the economy. As one of the universities mandate to spearhead the transformation process, Adama Science and Technology University (ASTU) is looking forward to excel in science and technology. Its goal is to develop highly qualified, capable, competent, and innovative human resource in the field of science and technology so as to transfer relevant scientific knowledge and skills required for nation building. The university also committed to conduct need based problem solving researches for alleviating the problems of the region and the country at large. To this end the university is working in collaboration with industries in its vicinity whereby its staff members are contributing a great deal in alleviating problems. Moreover, ASTU has set centers of excellence as a platform where academia can meet stakeholders. ASTU’s development into a full-fledged science and technology university has helped it to forge strong linkage, cooperation, and partnership with various national and international universities, development sectors, stake-holders, and relevant personalities. To showcase its all-round efforts, ASTU has organized the 2nd Deep Learning Indaba-X Ethiopia Conference 2021 on “Strengthening Awareness and Application of Machine Learning and Artificial Intelligence in Ethiopia”. This is a broad agenda that is seen as a part of the national plan of transformation of the country. Thus, this research confrence aims to further strengthen the contribution of ASTU in development endeavours of the country at large.