Chemical Composition and Antiproliferative Activity of the Ethanolic Extract of <i>Cyperus articulatus</i> L. (Cyperaceae)
Éden Bruno Sousa da Silva,
Lauro Euclides Soares Barata,
Michelly Rios Arévalo,
Leda Quercia Vieira,
Waldionê Castro,
Ana Lúcia Tasca Gois Ruiz,
Adriana Della Torre,
Kelly Christina Ferreira Castro,
Adilson Sartoratto,
Leopoldo C. Baratto,
Maxwell Barbosa de Santana,
Antonio Humberto Hamad Minervino,
Waldiney Pires Moraes
Affiliations
Éden Bruno Sousa da Silva
Laboratory of Pharmacology, Institute of Public Health—(ISCO), Federal University of Western Pará (UFOPA), Santarém 68040-255, PA, Brazil
Lauro Euclides Soares Barata
P&DBIO-Laboratory of Bioactive Natural Products, Institute of Biodiversity and Forests (IBEF), Federal University of Western Pará (UFOPA), Santarém 68040-255, PA, Brazil
Michelly Rios Arévalo
P&DBIO-Laboratory of Bioactive Natural Products, Institute of Biodiversity and Forests (IBEF), Federal University of Western Pará (UFOPA), Santarém 68040-255, PA, Brazil
Leda Quercia Vieira
Laboratory of Gnotobiology and Immunology (LAGI), Department of Biochemistry and Immunology, Institute of Biological Sciences (ICB), Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil
Waldionê Castro
Laboratory of Gnotobiology and Immunology (LAGI), Department of Biochemistry and Immunology, Institute of Biological Sciences (ICB), Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil
Ana Lúcia Tasca Gois Ruiz
Laboratory of Gnotobiology and Immunology (LAGI), Department of Biochemistry and Immunology, Institute of Biological Sciences (ICB), Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil
Adriana Della Torre
Laboratory of Gnotobiology and Immunology (LAGI), Department of Biochemistry and Immunology, Institute of Biological Sciences (ICB), Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil
Kelly Christina Ferreira Castro
P&DBIO-Laboratory of Bioactive Natural Products, Institute of Biodiversity and Forests (IBEF), Federal University of Western Pará (UFOPA), Santarém 68040-255, PA, Brazil
Adilson Sartoratto
Laboratory of Pharmacognosy, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-599, RJ, Brazil
Leopoldo C. Baratto
Laboratory of Pharmacognosy, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-599, RJ, Brazil
Maxwell Barbosa de Santana
Laboratory of Pharmacology, Institute of Public Health—(ISCO), Federal University of Western Pará (UFOPA), Santarém 68040-255, PA, Brazil
Antonio Humberto Hamad Minervino
Laboratory of Animal Health, LARSANA, Federal University of Western Pará, UFOPA, Santarém 68040-255, PA, Brazil
Waldiney Pires Moraes
Laboratory of Pharmacology, Institute of Public Health—(ISCO), Federal University of Western Pará (UFOPA), Santarém 68040-255, PA, Brazil
Cyperus articulatus L. (Priprioca) is a plant of the Cyperaceae family traditionally used in traditional medicine in the Amazon region. Studies of the essential oil of this species have identified many terpene compounds. However, little is known about the possible uses of solid waste generated by the extraction of essential oils. This study aimed to investigate the chemical composition of volatile compounds and to evaluate the antiproliferative activity of the ethanolic extract of solid residues generated by the extraction of the essential oil of C. articulatus L. rizhomes in experimental models in vitro using peritoneal macrophages of mice and human tumor cell lines. The analysis of the chemical composition of volatile compounds indicated the presence of sesquiterpenes and particularly sequiterpenic ketones as main constituents. The results showed that the treatment with ethanolic extract of C. articulatus L. reduced the activity of the enzyme arginase and proliferation of cancer cells (p p C. articulatus L. exerts antiproliferative activity (p < 0.0001) with low toxicity on healthy cells in experimental models in vitro.
