PSPC1 potentiates TGF-β-dependent metastatic dissemination

Abstract

Metastatic reprogramming toward malignant tumor progression relies on the activation of oncogenic regulators, yet the cellular determinants remain elucidated. Through identification of aberrant prognostic cancer genes, we identified paraspeckle component 1 (PSPC1) functions as a master activator of metastatic reprogramming by activating epithelial-to-mesenchymal transition (EMT), stemness and TGF-β1 pro-metastatic switch.

Keywords

• pspc1
• emt
• cscs and tgf-β1 pro-metastatic reprogramming