Pd(OAc)2-catalyzed asymmetric hydrogenation of sterically hindered N-tosylimines

Jianzhong Chen; Zhenfeng Zhang; Bowen Li; Feilong Li; Yulin Wang; Min Zhao; Ilya D. Gridnev; Tsuneo Imamoto; Wanbin Zhang

doi:10.1038/s41467-018-07462-w

Nature Communications (Nov 2018)

Pd(OAc)2-catalyzed asymmetric hydrogenation of sterically hindered N-tosylimines

Jianzhong Chen,
Zhenfeng Zhang,
Bowen Li,
Feilong Li,
Yulin Wang,
Min Zhao,
Ilya D. Gridnev,
Tsuneo Imamoto,
Wanbin Zhang

Affiliations

Jianzhong Chen: Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University
Zhenfeng Zhang: Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University
Bowen Li: Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University
Feilong Li: School of Chemistry and Molecular Engineering, East China University of Science and Technology
Yulin Wang: School of Chemistry and Molecular Engineering, East China University of Science and Technology
Min Zhao: School of Chemistry and Molecular Engineering, East China University of Science and Technology
Ilya D. Gridnev: Department of Chemistry, Graduate School of Science, Tohoku University, Aramaki 3-6, Aoba-ku
Tsuneo Imamoto: Department of Chemistry, Graduate School of Science, Chiba University
Wanbin Zhang: Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University

DOI: https://doi.org/10.1038/s41467-018-07462-w
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 10

Abstract

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Sterically hindered unsaturated compounds are challenging substrates for asymmetric hydrogenation. Here, the authors report a palladium/chiral (bis)phosphine catalytic system that hydrogenates a number of hindered N-tosylimines with excellent enantioselectivitites.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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