Perspectives of using circulating tumor dna as a marker of malignant neoplasms’ status

Abstract

In this article the review of genetic analysis of circulating tumor DNA as one of the most intensively studied diagnostic methods in oncology is present. Due to its high sensitivity and specifi city and the ability to be used in solving diff erent clinical problems such as diagnosing and then monitoring of tumor burden, evaluating the probability of disease relapse and also correction of therapy used in case of detecting tumor’s resistance to it, this method is one of the most perspective to be implemented into public healthcare. Nevertheless, its high cost, a little quantity of clinical trials and necessity of standardization cannot aff ord this method to be used in clinic now.

Keywords

• circulating tumor dna
• oncology
• cancer diagnostics
• cancer biomarkers