Serum MMP3 and IL1-RA levels may be useful biomarkers for detecting asthma and chronic obstructive pulmonary disease overlap in patients with asthma

Kazufumi Takada, MD; Maho Suzukawa, MD, PhD; Hiroyuki Tashimo, MD, PhD; Nobuharu Ohshima, MD, PhD; Yuma Fukutomi, MD, PhD; Nobuyuki Kobayashi, MD; Masami Taniguchi, MD, PhD; Masaki Ishii, MD, PhD; Masahiro Akishita, MD, PhD; Ken Ohta, MD, PhD

World Allergy Organization Journal (Nov 2023)

Serum MMP3 and IL1-RA levels may be useful biomarkers for detecting asthma and chronic obstructive pulmonary disease overlap in patients with asthma

Kazufumi Takada, MD,
Maho Suzukawa, MD, PhD,
Hiroyuki Tashimo, MD, PhD,
Nobuharu Ohshima, MD, PhD,
Yuma Fukutomi, MD, PhD,
Nobuyuki Kobayashi, MD,
Masami Taniguchi, MD, PhD,
Masaki Ishii, MD, PhD,
Masahiro Akishita, MD, PhD,
Ken Ohta, MD, PhD

Affiliations

Kazufumi Takada, MD: Clinical Research Center, National Hospital Organization Tokyo National Hospital, Tokyo, 204-8585, Japan; Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, 113-8655, Japan
Maho Suzukawa, MD, PhD: Clinical Research Center, National Hospital Organization Tokyo National Hospital, Tokyo, 204-8585, Japan; Corresponding author. Clinical Research Center, National Hospital Organization Tokyo National Hospital, 3-1-1 Takeoka, Kiyose-City, Tokyo, 204-8585, Japan.
Hiroyuki Tashimo, MD, PhD: Asthma, Allergy and Rheumatology Center, National Hospital Organization Tokyo National Hospital, Tokyo, 204-8585, Japan
Nobuharu Ohshima, MD, PhD: Department of Respiratory Medicine, National Hospital Organization Tokyo National Hospital, Tokyo, 204-8585, Japan
Yuma Fukutomi, MD, PhD: Clinical Research Center, National Hospital Organization Sagamihara National Hospital, Kanagawa, 252-0392, Japan
Nobuyuki Kobayashi, MD: Fureai Machida Hospital, Tokyo, 194-0215, Japan
Masami Taniguchi, MD, PhD: Clinical Research Center, National Hospital Organization Sagamihara National Hospital, Kanagawa, 252-0392, Japan; Shonan Kamakura General Hospital, Kanagawa, 247-8533, Japan
Masaki Ishii, MD, PhD: Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, 113-8655, Japan
Masahiro Akishita, MD, PhD: Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, 113-8655, Japan
Ken Ohta, MD, PhD: Clinical Research Center, National Hospital Organization Tokyo National Hospital, Tokyo, 204-8585, Japan; Japan Anti-Tuberculosis Association, JATA Fukujuji Hospital, Tokyo, 204-8522, Japan

Journal volume & issue: Vol. 16, no. 11
p. 100840

Abstract

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Background: Asthma and chronic obstructive pulmonary disease (COPD) overlap (ACO) is characterized by concurrent features of asthma and COPD. Since disease pathogenesis, severities, and treatments differ between asthma and ACO, it is important to differentiate them. Objective: To clarify and compare the characteristics of ACO and asthma and identify the serum biomarkers for differentiating them, especially in older patients. Methods: This study used the data of 639 participants from the nationwide cohort study, the NHOM-Asthma study, an asthma registry in Japan, with complete information on smoking history, respiratory function, and serum biomarkers. ACO was defined as the self-reported comorbidity of COPD or emphysema, or with obstructive pulmonary function and smoking history (pack-years≥10). The clinical characteristics of patients with ACO and asthma without COPD were compared. The serum biomarkers for differentiation were examined using receiver operating characteristic curves and multivariable analysis. The associations between the biomarkers and age were also analyzed. Results: Of the 639 asthma patients, 125 (19.6%) were diagnosed with ACO; these patients were older and male-dominant and had a higher prevalence of comorbidities such as hypertension, diabetes, and stroke. Among the serum biomarkers that were significantly different between ACO and asthma without COPD, the YKL-40/CHI3L1, MMP3, and IL-1RA levels showed a high area under the curve for discriminating ACO. Only the MMP3 and IL-1RA levels were significantly higher among ACO patients, regardless of age and sex; the YKL-40/CHI3L1 levels were not different due to the effect of age. Conclusion: MMP3 and IL-1RA may be useful serum biomarkers for distinguishing ACO from asthma.

Published in World Allergy Organization Journal

ISSN: 1939-4551 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: https://www.sciencedirect.com/journal/world-allergy-organization-journal

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