Molecules (Oct 2009)

Design and Synthesis of Novel 2-Phenylaminopyrimidine (PAP) Derivatives and Their Antiproliferative Effects in Human Chronic Myeloid Leukemia Cells

  • Jin-Hua Dong,
  • Jian Wang,
  • Sheng Chang,
  • Yong-Kui Jing,
  • Shi-Liang Yin

DOI
https://doi.org/10.3390/molecules14104166
Journal volume & issue
Vol. 14, no. 10
pp. 4166 – 4179

Abstract

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A series of novel 2-phenylaminopyrimidine (PAP) derivatives structurally related to STI-571 were designed and synthesized. The abilities of these compounds to inhibit proliferation were tested in human chronic myeloid leukemia K562 cells. (E)-3-(2-bromophenyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)phenyl]acrylamide(12d) was the most effective cell growth inhibitor and was 3-fold more potent than STI-571.

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