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The Role of BPIFA1 in Upper Airway Microbial Infections and Correlated Diseases

BioMed Research International. 2018;2018 DOI 10.1155/2018/2021890


Journal Homepage

Journal Title: BioMed Research International

ISSN: 2314-6133 (Print); 2314-6141 (Online)

Publisher: Hindawi Limited

LCC Subject Category: Medicine

Country of publisher: United Kingdom

Language of fulltext: English

Full-text formats available: PDF, HTML, ePUB, XML



Yung-An Tsou (Department of Otolaryngology Head and Neck Surgery, School of Medicine, China Medical University Hospital, Taichung 404, Taiwan)

Min-Che Tung (Department of Surgery, Tungs’ Taichung MetroHarbor Hospital, Taichung 435, Taiwan)

Katherine A. Alexander (Department of Biology, Washington University in St. Louis, St. Louis, Missouri 63130, USA)

Wen-Dien Chang (Department of Sport Performance, National Taiwan University of Sport, Taichung 404, Taiwan)

Ming-Hsui Tsai (Department of Otolaryngology Head and Neck Surgery, School of Medicine, China Medical University Hospital, Taichung 404, Taiwan)

Hsiao-Ling Chen (Department of Bioresources, Da-Yeh University, Changhwa 515, Taiwan)

Chuan-Mu Chen (Department of Life Sciences, National Chung Hsing University, Taichung 402, Taiwan)


Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 19 weeks


Abstract | Full Text

The mucosa is part of the first line of immune defense against pathogen exposure in humans and prevents viral and bacterial infection of the soft palate, lungs, uvula, and nasal cavity that comprise the ear-nose-throat (ENT) region. Bactericidal/permeability-increasing fold containing family A, member 1 (BPIFA1) is a secretory protein found in human upper aerodigestive tract mucosa. This innate material is secreted in mucosal fluid or found in submucosal tissue in the human soft palate, lung, uvula, and nasal cavity. BPIFA1 is a critical component of the innate immune response that prevents upper airway diseases. This review will provide a brief introduction of the roles of BPIFA1 in the upper airway (with a focus on the nasal cavity, sinus, and middle ear), specifically its history, identification, distribution in various human tissues, function, and diagnostic value in various upper airway infectious diseases.