Nature Communications (Dec 2022)
Multi-omics identify falling LRRC15 as a COVID-19 severity marker and persistent pro-thrombotic signals in convalescence
- Jack S. Gisby,
- Norzawani B. Buang,
- Artemis Papadaki,
- Candice L. Clarke,
- Talat H. Malik,
- Nicholas Medjeral-Thomas,
- Damiola Pinheiro,
- Paige M. Mortimer,
- Shanice Lewis,
- Eleanor Sandhu,
- Stephen P. McAdoo,
- Maria F. Prendecki,
- Michelle Willicombe,
- Matthew C. Pickering,
- Marina Botto,
- David C. Thomas,
- James E. Peters
Affiliations
- Jack S. Gisby
- Centre for Inflammatory Disease, Dept of Immunology and Inflammation, Imperial College London
- Norzawani B. Buang
- Centre for Inflammatory Disease, Dept of Immunology and Inflammation, Imperial College London
- Artemis Papadaki
- Centre for Inflammatory Disease, Dept of Immunology and Inflammation, Imperial College London
- Candice L. Clarke
- Centre for Inflammatory Disease, Dept of Immunology and Inflammation, Imperial College London
- Talat H. Malik
- Centre for Inflammatory Disease, Dept of Immunology and Inflammation, Imperial College London
- Nicholas Medjeral-Thomas
- Centre for Inflammatory Disease, Dept of Immunology and Inflammation, Imperial College London
- Damiola Pinheiro
- Centre for Inflammatory Disease, Dept of Immunology and Inflammation, Imperial College London
- Paige M. Mortimer
- Centre for Inflammatory Disease, Dept of Immunology and Inflammation, Imperial College London
- Shanice Lewis
- Centre for Inflammatory Disease, Dept of Immunology and Inflammation, Imperial College London
- Eleanor Sandhu
- Centre for Inflammatory Disease, Dept of Immunology and Inflammation, Imperial College London
- Stephen P. McAdoo
- Centre for Inflammatory Disease, Dept of Immunology and Inflammation, Imperial College London
- Maria F. Prendecki
- Centre for Inflammatory Disease, Dept of Immunology and Inflammation, Imperial College London
- Michelle Willicombe
- Centre for Inflammatory Disease, Dept of Immunology and Inflammation, Imperial College London
- Matthew C. Pickering
- Centre for Inflammatory Disease, Dept of Immunology and Inflammation, Imperial College London
- Marina Botto
- Centre for Inflammatory Disease, Dept of Immunology and Inflammation, Imperial College London
- David C. Thomas
- Centre for Inflammatory Disease, Dept of Immunology and Inflammation, Imperial College London
- James E. Peters
- Centre for Inflammatory Disease, Dept of Immunology and Inflammation, Imperial College London
- DOI
- https://doi.org/10.1038/s41467-022-35454-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 21
Abstract
End-stage kidney disease confers a high risk for severe COVID-19 infection. Using an at-risk group (end-stage kidney disease patients with COVID-19), authors using RNA-sequencing of immune cells and plasma proteomic profiling to investigate the host response to viral infection.
