Phenytoin-induced cerebellar atrophy: A case for reversibility of neurological decline

Abstract

This case serves as a reminder of the infrequent, yet consequential occurrence of cerebellar degeneration linked to phenytoin usage. Whilst emphasizes the importance of monitoring patients on long-term phenytoin therapy, and it further suggests considering employing bedside imaging tools such as Ultrasound fusion imaging for follow-up of patients at risk of this type of disorder. We present a case study involving a 23-year-old woman who experienced significant neurological impairment resulting in severe cerebellar atrophy while undergoing phenytoin treatment. On cessation of phenytoin, the patient exhibited improvement with enhanced cerebellar function.

Keywords

• Anticonvulsant
• Ataxia
• Apoptosis
• Drug-Related side effects and adverse reactions
• Nystagmus
• Pathologic