Creatine - the impact of supplementation on the human body

Abstract

Introduction Creatine is an endogenously occurring compound in the human body and one of the most extensively studied dietary supplements used worldwide. It is synthesized in the human body, primarily in the kidneys and liver, and is supplied through a diet rich in animal-based foods. Creatine is a nitrogenous compound composed of three amino acids: glycine, arginine, and methionine. It plays a crucial role in the body's metabolism, and therefore, the function of many organs and systems depends on its levels. Aim of the study The aim of this study was to discuss the role that creatine plays in the body. A summary of the effects of creatine supplementation in sports and various disease conditions was provided. The study also explored the metabolism of creatine and focused on the best available form of creatine and its dosing regimen. Materials and methods The study was based on articles searched in the PubMed database, published between 2006 and 2023. The following keywords were used for the search: "creatine," "creatine supplementation," "creatine monohydrate," "creatine supplement," and "creatine effects." Conclusion Creatine is one of the most popular chemical compounds that occur endogenously in the muscle cells of the body. It is a nitrogenous compound primarily produced in the liver, and its levels can be further increased with creatine supplements. The most widely available and well-studied form on the market is creatine monohydrate. Until recently, creatine supplementation was only associated with sports, but it is now used in various disease conditions and supports the function of many organs.

Keywords

• Creatine
• creatine supplementation
• creatine monohydrate
• creatine supplement