Nature Communications (May 2021)

Asymmetric cell division shapes naive and virtual memory T-cell immunity during ageing

  • Mariana Borsa,
  • Niculò Barandun,
  • Fabienne Gräbnitz,
  • Isabel Barnstorf,
  • Nicolas S. Baumann,
  • Katharina Pallmer,
  • Samira Baumann,
  • Dominique Stark,
  • Miroslav Balaz,
  • Nathalie Oetiker,
  • Franziska Wagen,
  • Christian Wolfrum,
  • Anna Katharina Simon,
  • Nicole Joller,
  • Yves Barral,
  • Roman Spörri,
  • Annette Oxenius

DOI
https://doi.org/10.1038/s41467-021-22954-y
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

Read online

Asymmetrical cell division helps to maintain cellular heterogeneity in the T cell compartment. Here the authors examine the differential immune responses built by naive and virtual memory T cells from young and aged individuals, and explore the effect of mTOR inhibition on asymmetrical cell division and memory formation.