Nature Communications (Nov 2020)
An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline
- Hanna Trzeciakiewicz,
- Deepa Ajit,
- Jui-Heng Tseng,
- Youjun Chen,
- Aditi Ajit,
- Zarin Tabassum,
- Rebecca Lobrovich,
- Claire Peterson,
- Natallia V. Riddick,
- Michelle S. Itano,
- Ashutosh Tripathy,
- Sheryl S. Moy,
- Virginia M. Y. Lee,
- John Q. Trojanowski,
- David J. Irwin,
- Todd J. Cohen
Affiliations
- Hanna Trzeciakiewicz
- Department of Biochemistry and Biophysics, University of North Carolina
- Deepa Ajit
- Department of Neurology, UNC Neuroscience Center, University of North Carolina
- Jui-Heng Tseng
- Department of Neurology, UNC Neuroscience Center, University of North Carolina
- Youjun Chen
- Department of Neurology, UNC Neuroscience Center, University of North Carolina
- Aditi Ajit
- Department of Neurology, UNC Neuroscience Center, University of North Carolina
- Zarin Tabassum
- Department of Neurology, UNC Neuroscience Center, University of North Carolina
- Rebecca Lobrovich
- Penn Digital Neuropathology Laboratory, Department of Neurology, Perelman School of Medicine, University of Pennsylvania
- Claire Peterson
- Penn Digital Neuropathology Laboratory, Department of Neurology, Perelman School of Medicine, University of Pennsylvania
- Natallia V. Riddick
- Division of Comparative Medicine, University of North Carolina
- Michelle S. Itano
- Department of Cell Biology and Physiology, Carolina Institute for Developmental Disabilities, UNC Neuroscience Center, University of North Carolina
- Ashutosh Tripathy
- Department of Biochemistry and Biophysics, University of North Carolina
- Sheryl S. Moy
- Department of Psychiatry, Carolina Institute for Developmental Disabilities, University of North Carolina
- Virginia M. Y. Lee
- Department of Pathology & Laboratory Medicine, Center for Neurodegenerative Disease Research (CNDR), Institute on Aging, Perelman School of Medicine, University of Pennsylvania
- John Q. Trojanowski
- Department of Pathology & Laboratory Medicine, Center for Neurodegenerative Disease Research (CNDR), Institute on Aging, Perelman School of Medicine, University of Pennsylvania
- David J. Irwin
- Penn Digital Neuropathology Laboratory, Department of Neurology, Perelman School of Medicine, University of Pennsylvania
- Todd J. Cohen
- Department of Biochemistry and Biophysics, University of North Carolina
- DOI
- https://doi.org/10.1038/s41467-020-19317-4
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
HDAC6 is a tau deacetylase and acetylation of tau inhibits its function and promotes aggregation. Here the authors show that HDAC6 protects against tau accumulation in a mouse model of tauopathy.
