Clinicopathologic Analysis of Sinonasal Inverted Papilloma, with Focus on Human Papillomavirus Infection Status
Munechika Tsumura,
Seiichiro Makihara,
Asami Nishikori,
Yuka Gion,
Toshiaki Morito,
Shotaro Miyamoto,
Tomoyuki Naito,
Kensuke Uraguchi,
Aiko Oka,
Tomoyasu Tachibana,
Yorihisa Orita,
Shin Kariya,
Mitsuhiro Okano,
Mizuo Ando,
Yasuharu Sato
Affiliations
Munechika Tsumura
Department of Otolaryngology Head and Neck Surgery, Kagawa Rosai Hospital, Marugame 763-8502, Japan
Seiichiro Makihara
Department of Otolaryngology Head and Neck Surgery, Kagawa Rosai Hospital, Marugame 763-8502, Japan
Asami Nishikori
Division of Pathophysiology, Graduate School of Health Sciences, Okayama University, Okayama 700-8558, Japan
Yuka Gion
Division of Pathophysiology, Graduate School of Health Sciences, Okayama University, Okayama 700-8558, Japan
Toshiaki Morito
Department of Pathology, Kagawa Rosai Hospital, Marugame 763-8502, Japan
Shotaro Miyamoto
Department of Otolaryngology Head and Neck Surgery, Kagawa Rosai Hospital, Marugame 763-8502, Japan
Tomoyuki Naito
Department of Otorhinolaryngology, Kagawa Prefectural Central Hospital, Takamatsu 760-8557, Japan
Kensuke Uraguchi
Department of Otolaryngology Head and Neck Surgery, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University, Okayama 700-8558, Japan
Aiko Oka
Department of Otorhinolaryngology, School of Medicine, International University of Health and Welfare, Narita 286-8520, Japan
Tomoyasu Tachibana
Department of Otolaryngology, Japanese Red Cross Society Himeji Hospital, Himeji 670-8540, Japan
Yorihisa Orita
Department of Otolaryngology Head and Neck Surgery, Graduate School of Medicine, Kumamoto University, Kumamoto 860-8556, Japan
Shin Kariya
Department of Otolaryngology Head and Neck Surgery, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University, Okayama 700-8558, Japan
Mitsuhiro Okano
Department of Otorhinolaryngology, School of Medicine, International University of Health and Welfare, Narita 286-8520, Japan
Mizuo Ando
Department of Otolaryngology Head and Neck Surgery, Dentistry and Pharmaceutical Sciences, Graduate School of Medicine, Okayama University, Okayama 700-8558, Japan
Yasuharu Sato
Division of Pathophysiology, Graduate School of Health Sciences, Okayama University, Okayama 700-8558, Japan
Sinonasal inverted papilloma (SNIP) can recur; however, the factors related to tumor recurrence remain unclear. This study aimed to analyze risk factors, including human papillomavirus (HPV) infection, as well as other factors associated with SNIP recurrence. Thirty-two patients who were diagnosed with SNIP and underwent surgery between 2010 and 2019 were enrolled: 24 men and 8 women, with a mean age of 59.2 years. The mean follow-up was 57.3 months. Demographics and information about history of smoking, diabetes mellitus (DM), hypertension, allergic rhinitis, alcohol consumption, tumor stage, surgical approach, and recurrence were reviewed retrospectively. Specimens were investigated using polymerase chain reaction to detect HPV DNA (high-risk subtypes: 16, 18, 31, 33, 35, 52b, and 58; low-risk subtypes: 6 and 11). Seven patients (21.9%) experienced recurrence. HPV DNA was detected in five (15.6%) patients (high-risk subtypes, n = 2; low-risk subtypes, n = 3). Patients with recurrence of SNIP had a higher proportion of young adults and displayed higher rates of HPV infection, DM, and advanced tumor stage than those without recurrence. HPV infection, young adulthood, DM, and advanced tumor stage could be associated with a high recurrence rate, which suggests that patients with these risk factors could require close follow-up after surgery.
