ETHNIC PATTERNS OF PREECLAMPSIA

Abstract

Pre-eclampsia is one of the most dangerous complications of pregnancy and increases the risk of adverse outcomes for both mother and fetus. Objective: to study the course of pregnancy, circadian blood pressure profile, autonomic regulation of the heart and metabolic systems in pregnant Buryat women with pre-eclampsia. To achieve the objectives of the research we have studied pregnancy courses and birth outcomes in 581 women. For the analysis wereformed thefollowing groups; the Igroup 240 pregnant Buryat women with pre-eclampsia; II group 341 pregnant Russian women with pre-eclampsia. In all patients we evaluated hematological, biochemical and hemostatic data as soon as perform daily monitoring of blood pressure. Our studies have shown that Buryat women developed early severe pre-eclampsia early, demonstrated no response for treatment with requiring early surgical delivery. Hemostasis changes in preeclampsia in pregnant Buryat women indicate the prevalence of vascular-platelet disorders (F = 27,18). Their circadian blood pressure profile is characterized by a lack of pressure reduction at night, in a paradoxical increase of mean dynamic blood pressure at night (F = 27,18) as soon as Russian pregnant had higher rates of maximum systolic and diastolic blood pressure during the day (F=30,29). The autonomic regulation of the heart function in pregnant Buryat women with pre-eclampsia is characterized by imbalance in parasympathetic and sympathetic innervation with vagotonia domination as in the daytime and at night, which increasing with severity progression of the pre-eclampsia. High daytime level of VLF-in Buriat women with severe pre-eclampsia evidences of stress adaptation processes.

Keywords

• pre-eclampsia
• ethnic group
• heart rate variability
• hemostasis