Two Different Strains of Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) in North and South Osaka by Phylogenetic Analysis of Evolutionary Lineage: Evidence for Independent SFTSV Transmission
Ryo Ikemori,
Ikuko Aoyama,
Tadahiro Sasaki,
Hirono Takabayashi,
Kazutoshi Morisada,
Masaru Kinoshita,
Kazuyoshi Ikuta,
Takahiro Yumisashi,
Kazushi Motomura
Affiliations
Ryo Ikemori
Virology Section, Division of Microbiology, Osaka Institute of Public Health, Osaka 537-0025, Japan
Ikuko Aoyama
Virology Section, Division of Microbiology, Osaka Institute of Public Health, Osaka 537-0025, Japan
Tadahiro Sasaki
Virology Section, Division of Microbiology, Osaka Institute of Public Health, Osaka 537-0025, Japan
Hirono Takabayashi
Fujiidera Public Health Center, Fujiidera, Osaka 583-0024, Japan
Kazutoshi Morisada
Takatsuki-City Public Health Center, Takatsuki, Osaka 569-0052, Japan
Masaru Kinoshita
Department of Health and Medical Care, Osaka Prefectural Government, Osaka 540-8570, Japan
Kazuyoshi Ikuta
Virology Section, Division of Microbiology, Osaka Institute of Public Health, Osaka 537-0025, Japan
Takahiro Yumisashi
Virology Section, Division of Microbiology, Osaka Institute of Public Health, Osaka 537-0025, Japan
Kazushi Motomura
Virology Section, Division of Microbiology, Osaka Institute of Public Health, Osaka 537-0025, Japan
Severe fever with thrombocytopenia syndrome (SFTS) is a novel tick-borne infectious disease, therefore, the information on the whole genome of the SFTS virus (SFTSV) is still limited. This study demonstrates a nearly whole genome of the SFTSV identified in Osaka in 2017 and 2018 by next-generation sequencing (NGS). The evolutionary lineage of two genotypes, C5 and J1, was identified in Osaka. The first case in Osaka belongs to suspect reassortment (L:C5, M:C5, S:C4), the other is genotype J1 (L: J1, M: J1, S: J1) according to the classification by a Japanese group. C5 was identified in China, indicating that C5 identified in this study may be transmitted by birds between China and Japan. This study revealed that different SFTSV genotypes were distributed in two local areas, suggesting the separate or focal transmission patterns in Osaka.
