Synthesis, Kinetics, Reaction Mechanism and Biological Activity Studies of Novel 1, 3-Oxazine Compound

Abstract

A novel 1, 3-Oxazine compound ((E)-8-benzylidene-2-(4-methoxyphenyl)-3,4-diphenyl -3,4,5,6,7,8-hexahydro-2H-benzo[e][1,3]oxazine) was synthesized by reaction of N-(4-methoxybenzylidene)aniline(Schiff base) with 2,6-di((E)-benzylidene)cyclohexan-1-one(chalcone). The structure of 1, 3-Oxazine compound was characterized through spectral data (FT-IR, 1H- NMR and Ultraviolet-Visible spectrophotometer). The kinetics study of the novel synthesized 1, 3-Oxazine compound was studied to determine the order of the reaction and the mechanism pathway. It was found that the reaction is first order undergoes via (imino-Diels-Alder). The reaction rate, Arrhenius factor (A), thermodynamic functions (Ea (free energy of activation), DS#(entropy of activation), and DG# (Gibbs energy of activation)) were also calculated and confirmed the formation of 1, 3-Oxazine cycle. Finally, the antibacterial activities against gram negative (Escherichia coli) with gram positive (Staphylococcus aureus) were evaluated optical density for finding minimum inhibition concentration (MIC).

Keywords

• Schiff base
• Chalcone
• Biological Activity
• Kinetics
• Oxazine