Analysis of Antioxidant Constituents of Filtering Infusions from Oak (<i>Quercus sideroxyla</i> Bonpl. and <i>Quercus eduardii</i> Trel.) and Yerbaniz (<i>Tagetes lucida</i> (Sweet) Voss) as Monoamine Oxidase Inhibitors
Saúl Alberto Álvarez,
Nuria Elizabeth Rocha-Guzmán,
Jorge Alberto Sánchez-Burgos,
José Alberto Gallegos-Infante,
Martha Rocío Moreno-Jiménez,
Rubén Francisco González-Laredo,
Santiago Solís-González
Affiliations
Saúl Alberto Álvarez
Research Group on Functional Foods and Nutraceuticals, Department of Chemical and Biochemical Engineering, TecNM/Instituto Tecnológico de Durango, Felipe Pescador 1830 Ote., Durango 34080, Dgo., Mexico
Nuria Elizabeth Rocha-Guzmán
Research Group on Functional Foods and Nutraceuticals, Department of Chemical and Biochemical Engineering, TecNM/Instituto Tecnológico de Durango, Felipe Pescador 1830 Ote., Durango 34080, Dgo., Mexico
Jorge Alberto Sánchez-Burgos
Postgraduate Program in Food Sciences, TecNM/Instituto Tecnológico de Tepic, Avenida Tecnológico, Número 2595, Colonia Lagos del Country, Tepic 63175, Nayarit, Mexico
José Alberto Gallegos-Infante
Research Group on Functional Foods and Nutraceuticals, Department of Chemical and Biochemical Engineering, TecNM/Instituto Tecnológico de Durango, Felipe Pescador 1830 Ote., Durango 34080, Dgo., Mexico
Martha Rocío Moreno-Jiménez
Research Group on Functional Foods and Nutraceuticals, Department of Chemical and Biochemical Engineering, TecNM/Instituto Tecnológico de Durango, Felipe Pescador 1830 Ote., Durango 34080, Dgo., Mexico
Rubén Francisco González-Laredo
Research Group on Functional Foods and Nutraceuticals, Department of Chemical and Biochemical Engineering, TecNM/Instituto Tecnológico de Durango, Felipe Pescador 1830 Ote., Durango 34080, Dgo., Mexico
Santiago Solís-González
TecNM/I.T. El Salto, Calle Tecnológico # 101, Col. La Forestal, El Salto 34942, P.N. Durango, Mexico
The antioxidant constituents of ancestral products with ethnobotanical backgrounds are candidates for the study of filtering infusions to aid in pharmacotherapies focused on the treatment of depression and anxiety. Monoamine oxidase A (MAO-A) is an enzyme that regulates the metabolic breakdown of serotonin and noradrenaline in the nervous system. The goal of this study was to evaluate in vitro and in silico the effect of antioxidant constituents of filtering infusions from yerbaniz (Tagetes lucida (Sweet) Voss) and oak (Quercus sideroxyla Bonpl. and Quercus eduardii Trel.) as monoamine oxidase inhibitors. Materials were dried, ground, and mixed according to a simplex–centroid mixture design for obtaining infusions. Differential analysis of the phenolic constituent’s ratio in the different infusions indicates that among the main compounds contributing to MAO-A inhibition are the gallic, chlorogenic, quinic, and shikimic acids, quercetin glucuronide and some glycosylated derivatives of ellagic acid and ellagic acid methyl ether. Infusions of Q. sideroxyla Bonpl. leaves, because of their content (99.45 ± 5.17 µg/mg) and synergy between these constituents for MAO-A inhibition (52.82 ± 3.20%), have the potential to treat depression and anxiety. Therefore, future studies with pharmacological approaches are needed to validate them as therapeutic agents with applications in mental health care.
