Nature Communications (Mar 2021)
S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates
- Joshua G. Liang,
- Danmei Su,
- Tian-Zhang Song,
- Yilan Zeng,
- Weijin Huang,
- Jinhua Wu,
- Rong Xu,
- Peiwen Luo,
- Xiaofang Yang,
- Xiaodong Zhang,
- Shuangru Luo,
- Ying Liang,
- Xinglin Li,
- Jiaju Huang,
- Qiang Wang,
- Xueqin Huang,
- Qingsong Xu,
- Mei Luo,
- Anliang Huang,
- Dongxia Luo,
- Chenyan Zhao,
- Fan Yang,
- Jian-Bao Han,
- Yong-Tang Zheng,
- Peng Liang
Affiliations
- Joshua G. Liang
- Clover Biopharmaceuticals
- Danmei Su
- Clover Biopharmaceuticals
- Tian-Zhang Song
- Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences
- Yilan Zeng
- Public Health Clinical Center of Chengdu
- Weijin Huang
- Division of HIV/AIDS and Sex-Transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC)
- Jinhua Wu
- Clover Biopharmaceuticals
- Rong Xu
- Clover Biopharmaceuticals
- Peiwen Luo
- Clover Biopharmaceuticals
- Xiaofang Yang
- Clover Biopharmaceuticals
- Xiaodong Zhang
- Clover Biopharmaceuticals
- Shuangru Luo
- Clover Biopharmaceuticals
- Ying Liang
- Clover Biopharmaceuticals
- Xinglin Li
- Clover Biopharmaceuticals
- Jiaju Huang
- Clover Biopharmaceuticals
- Qiang Wang
- Clover Biopharmaceuticals
- Xueqin Huang
- Clover Biopharmaceuticals
- Qingsong Xu
- Clover Biopharmaceuticals
- Mei Luo
- Public Health Clinical Center of Chengdu
- Anliang Huang
- Department of Pathology, Chengdu Fifth People’s Hospital
- Dongxia Luo
- Public Health Clinical Center of Chengdu
- Chenyan Zhao
- Division of HIV/AIDS and Sex-Transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC)
- Fan Yang
- Department of Pathology, Chengdu Fifth People’s Hospital
- Jian-Bao Han
- Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences
- Yong-Tang Zheng
- Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences
- Peng Liang
- Clover Biopharmaceuticals
- DOI
- https://doi.org/10.1038/s41467-021-21634-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Vaccines for SARS-CoV-2 are needed to fight the pandemic. Here the authors show immunogenicity of an adjuvanted subunit vaccine, SARS-CoV-2 spike protein trimerized with trimer-tag technology, in small animal models and protection from SARS-CoV-2 challenge in non-human primates.
