Nature Communications (Feb 2019)
PLCβ2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of TAK1
- Lin Wang,
- Yilong Zhou,
- Zijuan Chen,
- Lei Sun,
- Juehui Wu,
- Haohao Li,
- Feng Liu,
- Fei Wang,
- Chunfu Yang,
- Juhao Yang,
- Qibin Leng,
- Qingli Zhang,
- Ajing Xu,
- Lisong Shen,
- Jinqiao Sun,
- Dianqing Wu,
- Caiyun Fang,
- Haojie Lu,
- Dapeng Yan,
- Baoxue Ge
Affiliations
- Lin Wang
- Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Yilong Zhou
- Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Zijuan Chen
- Department of Immunology, School of Basic Medical Sciences & Shanghai Public Health Clinical Center, Key Laboratory of Medical Molecular Virology of MOE/MOH, Fudan University
- Lei Sun
- School of Pharmacy, Shanghai Jiao Tong University
- Juehui Wu
- Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Haohao Li
- Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Feng Liu
- Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Fei Wang
- Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Chunfu Yang
- Institut Pasteur of Shanghai
- Juhao Yang
- Institut Pasteur of Shanghai
- Qibin Leng
- Institut Pasteur of Shanghai
- Qingli Zhang
- Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
- Ajing Xu
- Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
- Lisong Shen
- Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
- Jinqiao Sun
- Department of Clinical Immunology, Children’s Hospital of Fudan University
- Dianqing Wu
- Department of Pharmacology, Yale School of Medicine
- Caiyun Fang
- Department of Chemistry and Institutes of Biomedical Sciences, Fudan University
- Haojie Lu
- Department of Chemistry and Institutes of Biomedical Sciences, Fudan University
- Dapeng Yan
- Department of Immunology, School of Basic Medical Sciences & Shanghai Public Health Clinical Center, Key Laboratory of Medical Molecular Virology of MOE/MOH, Fudan University
- Baoxue Ge
- Shanghai Pulmonary Hospital, Tongji University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-019-08524-3
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Phospholipase C β (PLCβ) exhibits immuno-modulatory functions but its role in antiviral innate responses is unclear. Here, the authors provide evidence that PLCβ2 down regulates enterovirus-induced pro-inflammatory responses via inhibition of TAK1 activation, and suggest PLC as a potential therapeutic target.
