Nature Communications (Jan 2023)

Manipulation of sterol homeostasis for the production of 24-epi-ergosterol in industrial yeast

  • Yiqi Jiang,
  • Zhijiao Sun,
  • Kexin Lu,
  • Zeyu Wu,
  • Hailong Xue,
  • Li Zhu,
  • Guosi Li,
  • Yun Feng,
  • Mianbin Wu,
  • Jianping Lin,
  • Jiazhang Lian,
  • Lirong Yang

DOI
https://doi.org/10.1038/s41467-023-36007-z
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 11

Abstract

Read online

Brassinolide (BL) is one of the most active compounds among phytohormone brassinosteroids (BRs) and can be used for plant growth and development regulation. Here, the authors report the construction of an artificial pathway in baker’s yeast for scalable production of 24-epi-ergosterol, a precursor for BL semi-synthesis.