Cell Reports (Mar 2023)
Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep
- Elisabetta Iavarone,
- Jane Simko,
- Ying Shi,
- Marine Bertschy,
- María García-Amado,
- Polina Litvak,
- Anna-Kristin Kaufmann,
- Christian O’Reilly,
- Oren Amsalem,
- Marwan Abdellah,
- Grigori Chevtchenko,
- Benoît Coste,
- Jean-Denis Courcol,
- András Ecker,
- Cyrille Favreau,
- Adrien Christian Fleury,
- Werner Van Geit,
- Michael Gevaert,
- Nadir Román Guerrero,
- Joni Herttuainen,
- Genrich Ivaska,
- Samuel Kerrien,
- James G. King,
- Pramod Kumbhar,
- Patrycja Lurie,
- Ioannis Magkanaris,
- Vignayanandam Ravindernath Muddapu,
- Jayakrishnan Nair,
- Fernando L. Pereira,
- Rodrigo Perin,
- Fabien Petitjean,
- Rajnish Ranjan,
- Michael Reimann,
- Liviu Soltuzu,
- Mohameth François Sy,
- M. Anıl Tuncel,
- Alexander Ulbrich,
- Matthias Wolf,
- Francisco Clascá,
- Henry Markram,
- Sean L. Hill
Affiliations
- Elisabetta Iavarone
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland; Corresponding author
- Jane Simko
- Laboratory of Neural Microcircuitry (LNMC), École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland
- Ying Shi
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland; Laboratory of Neural Microcircuitry (LNMC), École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland
- Marine Bertschy
- Laboratory of Neural Microcircuitry (LNMC), École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland
- María García-Amado
- Departamento de Anatomía, Histología y Neurociencia, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain
- Polina Litvak
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland
- Anna-Kristin Kaufmann
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland
- Christian O’Reilly
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland
- Oren Amsalem
- Department of Neurobiology, Hebrew University of Jerusalem, Jerusalem, Israel
- Marwan Abdellah
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland
- Grigori Chevtchenko
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland
- Benoît Coste
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland
- Jean-Denis Courcol
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland
- András Ecker
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland
- Cyrille Favreau
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland
- Adrien Christian Fleury
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland
- Werner Van Geit
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland
- Michael Gevaert
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland
- Nadir Román Guerrero
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland
- Joni Herttuainen
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland
- Genrich Ivaska
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland
- Samuel Kerrien
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland
- James G. King
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland
- Pramod Kumbhar
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland
- Patrycja Lurie
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland
- Ioannis Magkanaris
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland
- Vignayanandam Ravindernath Muddapu
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland
- Jayakrishnan Nair
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland
- Fernando L. Pereira
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland
- Rodrigo Perin
- Laboratory of Neural Microcircuitry (LNMC), École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland
- Fabien Petitjean
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland
- Rajnish Ranjan
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland
- Michael Reimann
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland
- Liviu Soltuzu
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland
- Mohameth François Sy
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland
- M. Anıl Tuncel
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland
- Alexander Ulbrich
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland
- Matthias Wolf
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland
- Francisco Clascá
- Departamento de Anatomía, Histología y Neurociencia, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain
- Henry Markram
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland; Laboratory of Neural Microcircuitry (LNMC), École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland
- Sean L. Hill
- Blue Brain Project, École polytechnique fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland; Department of Psychiatry, University of Toronto, Toronto, Canada; Department of Physiology, University of Toronto, Toronto, Canada; Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health (CAMH), Toronto, Canada; Corresponding author
- Journal volume & issue
-
Vol. 42,
no. 3
p. 112200
Abstract
Summary: Thalamoreticular circuitry plays a key role in arousal, attention, cognition, and sleep spindles, and is linked to several brain disorders. A detailed computational model of mouse somatosensory thalamus and thalamic reticular nucleus has been developed to capture the properties of over 14,000 neurons connected by 6 million synapses. The model recreates the biological connectivity of these neurons, and simulations of the model reproduce multiple experimental findings in different brain states. The model shows that inhibitory rebound produces frequency-selective enhancement of thalamic responses during wakefulness. We find that thalamic interactions are responsible for the characteristic waxing and waning of spindle oscillations. In addition, we find that changes in thalamic excitability control spindle frequency and their incidence. The model is made openly available to provide a new tool for studying the function and dysfunction of the thalamoreticular circuitry in various brain states.
