Nature Communications (Nov 2021)

Diesel2p mesoscope with dual independent scan engines for flexible capture of dynamics in distributed neural circuitry

  • Che-Hang Yu,
  • Jeffrey N. Stirman,
  • Yiyi Yu,
  • Riichiro Hira,
  • Spencer L. Smith

DOI
https://doi.org/10.1038/s41467-021-26736-4
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 8

Abstract

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Imaging of neuronal activity across distant brain regions is challenging. Here, the authors introduce a two-photon microscope with two independently controlled scan engines, and demonstrate calcium imaging with subcellular resolution in brain regions up to 7 mm apart simultaneously.