The TFIIH Subunit p89 (XPB) Localizes to the Centrosome during Mitosis

Achim Weber; Hye-Jung Chung; Erik Springer; Dirk Heitzmann; Richard Warth

doi:10.3233/CLO-2009-0509

Cellular Oncology (Jan 2010)

The TFIIH Subunit p89 (XPB) Localizes to the Centrosome during Mitosis

Achim Weber,
Hye-Jung Chung,
Erik Springer,
Dirk Heitzmann,
Richard Warth

Affiliations

Achim Weber: Department of Pathology, Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland
Hye-Jung Chung: Laboratory of Pathology, NCI, Center for Cancer Research, Bethesda, MD, USA
Erik Springer: Institute of Pathology, Johannes Gutenberg-University, Mainz, Germany
Dirk Heitzmann: Institute of Physiology, University of Regensburg, Regensburg, Germany
Richard Warth: Institute of Physiology, University of Regensburg, Regensburg, Germany

DOI: https://doi.org/10.3233/CLO-2009-0509
Journal volume & issue: Vol. 32, no. 1-2
pp. 121 – 130

Abstract

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Background: The general transcription factor II H (TFIIH), comprised of a core complex and an associated CAK-complex, functions in transcription, DNA repair and cell cycle control. Mutations of the two largest subunits, p89 (XPB) and p80 (XPD), cause the hereditary cancer-prone syndrome xeroderma pigmentosum.

Published in Cellular Oncology

ISSN: 1570-5870 (Print); 1875-8606 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Science: Biology (General): Cytology
Website: https://onlinelibrary.wiley.com/journal/2641

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