Serum Asprosin Correlates with Indirect Insulin Resistance Indices
Małgorzata Mirr,
Anna Braszak-Cymerman,
Aleksandra Ludziejewska,
Matylda Kręgielska-Narożna,
Paweł Bogdański,
Wiesław Bryl,
Maciej Owecki
Affiliations
Małgorzata Mirr
Department of Public Health, Poznan University of Medical Sciences, Rokietnicka St. 4, 60-806 Poznań, Poland
Anna Braszak-Cymerman
Department of Internal Diseases, Metabolic Disorders and Hypertension, Poznan University of Medical Sciences, Szamarzewskiego St. 84, 60-569 Poznań, Poland
Aleksandra Ludziejewska
Department of Laboratory Diagnostics, Poznan University of Medical Sciences, Szamarzewskiego St. 84, 60-569 Poznań, Poland
Matylda Kręgielska-Narożna
Department of Treatment of Obesity, Metabolic Disorders and Clinical Dietetics, Poznan University of Medical Sciences, Szamarzewskiego St. 84, 60-569 Poznań, Poland
Paweł Bogdański
Department of Treatment of Obesity, Metabolic Disorders and Clinical Dietetics, Poznan University of Medical Sciences, Szamarzewskiego St. 84, 60-569 Poznań, Poland
Wiesław Bryl
Department of Internal Diseases, Metabolic Disorders and Hypertension, Poznan University of Medical Sciences, Szamarzewskiego St. 84, 60-569 Poznań, Poland
Maciej Owecki
Department of Public Health, Poznan University of Medical Sciences, Rokietnicka St. 4, 60-806 Poznań, Poland
Background and Objectives: Insulin resistance is a major contributor to the development of type 2 diabetes and can be assessed using indirect indicators calculated from non-invasive tests. Asprosin is a recently discovered adipokine with a postulated effect on glycemic regulation. This study aimed to investigate the correlation between serum asprosin levels and insulin resistance indices. The correlation between circulating asprosin and obesity indices was also investigated. Materials and Methods: A total of 50 non-diabetic patients with obesity and 50 healthy volunteers were studied. Laboratory data, including circulating asprosin and anthropometric data, were collected. The following insulin resistance indices were calculated: triglyceride–glucose index (TyG), TyG–neck circumference (TyG–NC), TyG–neck circumference to height ratio (TyG–NHtR), TyG–waist circumference (TyG–WC), TyG–waist to height ratio (TyG–WHtR), TyG–body mass index (TyG–BMI), and the ratio between triglycerides and high-density cholesterol (TG/HDLc). The obtained data were analyzed separately for males and females. Results: Asprosin concentrations were significantly higher in obese patients (p p p p p < 0.001). Conclusions: Asprosin can be considered a marker of obesity and insulin resistance.
