Food and Agricultural Immunology (Dec 2023)

Potential effect of kaempferol against various malignancies: recent advances and perspectives

  • Muhammad Shahbaz,
  • Muhammad Imran,
  • Ushna Momal,
  • Hammad Naeem,
  • Suliman A. Alsagaby,
  • Waleed Al Abdulmonem,
  • Ahmed H. El-Ghorab,
  • Mohammed M. Ghoneim,
  • Muzzamal Hussain,
  • Mohamed E. Shaker,
  • Mohamed A. Abdelgawad,
  • Ahmed Mujtaba,
  • Entessar Al Jbawi

DOI
https://doi.org/10.1080/09540105.2023.2265690
Journal volume & issue
Vol. 34, no. 1

Abstract

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ABSTRACTKaempferol is a flavonoid present in many eatable plants. Researchers discovered a link between consuming foods high in kaempferol and lowering the threat for acquiring many diseases, including cardiovascular disease, diabetes, obesity and cancer. Kaempferol can inhibit AHR transcription, modulate ERK signalling pathway and NF-κB pathways, block MAPK and AP1 signalling pathways and perform more anticancer roles. Kaempferol also has the ability to act against diabetes via suppressed phosphorylation of (IKK) IkB kinase, (IRS-1) insulin receptor substrate-1 and (IKK) IkB kinase through the hepatic IKK/NF-B signalling pathways and significantly enhanced insulin secretion and synthesis. Kaempferol protects cardiomyocytes from anoxia/reoxygenation (A/R)-induced damage by lowering LDH release, improving cell survival, reducing A/R-induced ROS formation, and release of cytochrome c. This knowledge may aid in understanding health advantages of medicinal plants that contain kaempferol and may lead to the development of the flavonoid as a potential agents for disease aversion and therapy.

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