Cytoskeletal dynamics regulates stromal invasion behavior of distinct liver cancer subtypes

Ryan Y. Nguyen; Hugh Xiao; Xiangyu Gong; Alfredo Arroyo; Aidan T. Cabral; Tom T. Fischer; Kaitlin M. Flores; Xuchen Zhang; Marie E. Robert; Barbara E. Ehrlich; Michael Mak

doi:10.1038/s42003-022-03121-5

Communications Biology (Mar 2022)

Cytoskeletal dynamics regulates stromal invasion behavior of distinct liver cancer subtypes

Ryan Y. Nguyen,
Hugh Xiao,
Xiangyu Gong,
Alfredo Arroyo,
Aidan T. Cabral,
Tom T. Fischer,
Kaitlin M. Flores,
Xuchen Zhang,
Marie E. Robert,
Barbara E. Ehrlich,
Michael Mak

Affiliations

Ryan Y. Nguyen: Department of Biomedical Engineering, Yale University
Hugh Xiao: Department of Biomedical Engineering, Yale University
Xiangyu Gong: Department of Biomedical Engineering, Yale University
Alfredo Arroyo: Department of Pharmacology, Yale University
Aidan T. Cabral: Department of Biomedical Engineering, Yale University
Tom T. Fischer: Department of Pharmacology, Yale University
Kaitlin M. Flores: Department of Biomedical Engineering, Yale University
Xuchen Zhang: Department of Pathology, Yale University
Marie E. Robert: Department of Pathology, Yale University
Barbara E. Ehrlich: Department of Pharmacology, Yale University
Michael Mak: Department of Biomedical Engineering, Yale University

DOI: https://doi.org/10.1038/s42003-022-03121-5
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 17

Abstract

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Treatment for liver cancer is complicated by its various subtypes, which show different responses to anticancer drugs. This study demonstrates the effectiveness of targeting biophysical phenotypes related to cytoskeleton properties that are usually masked in traditional drug screens.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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